Tetracycline and niacinamide (TCN) were administered to 12 dogs with discoid lupus erythematosus (DLE), 3 dogs with perianal/perivulvar lupus erythematosus (PPLE), 1 dog with vesicular cutaneous lupus erythematosus (VCLE), and 1 dog with exfoliative cutaneous lupus erythematosus (ECLE). Eight of 12 dogs (67%) with DLE and 3 of 3 dogs (100%) with PPLE were satisfactorily controlled. The dog with ECLE had a partial response, and the dog with VCLE did not respond.
