Abstract
Glucocorticoid-induced adrenocortical suppression is a major concern in its systemic administration, rather than topical application, in the dog. We described the cases of two dogs respectively treated with triamcinolone acetonide combined cream for 3 months and hydrocortisone aceponate spray for 10 months. The dogs presented with skin lesions and adrenocortical suppression, which was confirmed by an ACTH stimulation test. Skin and adrenocortical function returned to normal after withdrawal of topical glucocorticoids. These results demonstrate that long-term use of topical glucocorticoids including an antedrug has the potential to affect the pituitary-adrenal system.
