Re-evaluation of the Cefovecin Disk Diffusion Test for Predicting Oxacillin-resistance in Staphylococcus pseudintermedius Isolated from Dogs

Abstract

The aim of this study was to re-evaluate the breakpoint of the cefovecin (CFV) disk diffusion test for predicting oxacillin (MPIPC)-resistance in Staphylococcus pseudintermedius isolated from dogs with pyoderma or healthy dogs. There was a significant positive correlation between CFV and the MPIPC disk diffusion zone diameters. The receiver operating characteristic curve revealed that the best CFV breakpoint for predicting MPIPC resistance was ≤25 mm. The concordance rate of the susceptibility and resistance to CFV and MPIPC in S. pseudintermedius was 96.9%. In summary, the CFV disk diffusion test with the newly estimated breakpoint is valid for the prediction of MPIPC-resistance in S. pseudintermedius.