Efficacy and safety of ozone-bubble bathing for seborrhea in dogs

Abstract

A controlled, comparative open study was conducted on the efficacy and safety of ozone-bubble bathing for seborrhea in dogs. Fourteen dogs were bathed for 10 minutes with 0.015 ppm ozone generated by a bubbling device. Seborrhea, hair shine, hair loss, dandruff, and odor were assessed before, immediately after (T0), and one week after bathing (T7). The Wilcoxon matched-pairs signed-rank tests was used for statistical analysis. The efficacy rate in terms of the number of improved cases for seborrhea was 92.9% (13 cases) at T0, and 71.4% (10 cases) at T7. On the other hand, the efficacy rates of simple bubble bathing without ozone for seborrhea were 33.3% at T0 and T7. The overall score improvement rate of seborrhea was 70.0% (p<0.01) at T0, and 40.0% (p<0.01) at T7. The effectiveness of the treatment was also assessed by the owners using a Visual Analog Scale. The efficacy rates were 85.7% at T0 and 78.6% at T7, and the overall improvement rates were 60.6% (p<0.01) at T0 and 37.9% (p<0.05) at T7. No adverse events or dropouts were observed during the study period. The results indicate that ozone-bubble bathing is clinically effective in treating seborrhea in dogs.