Japanese Journal of Veterinary Research
Online ISSN : 2758-447X
Print ISSN : 0047-1917
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Efficacy of totarol against Staphylococcus pseudintermedius and Staphylococcus coagulans in dogs and cats
An in vitro study
Manami TsunoiKeita IyoriKazuki Harada
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2024 Volume 71 Issue 4 Pages 117-120

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Abstract

We investigated the susceptibility of totarol in 20 staphylococci strains, consisting of Staphylococcus pseudintermedius (n = 10) and S. coagulans (n = 10), from dogs and cats with skin infections. Each species contained 5 methicillin-resistant and 5 methicillin-susceptible strains. The minimum inhibitory concentrations (MICs) of totarol were determined by microbroth dilution method. As a result, all strains had the MIC of 4 μg/mL, except for one methicillin-susceptible S. coagulans strain, which had the MIC of 40 μg/mL. These MICs were extremely lower than the totarol concentration in commercially-available topical products. The present findings would support the use of totarol-containing topical products as one of the treatment options for canine and feline skin infections with both methicillin-susceptible and -resistant staphylococci.

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© 2024 Japanese Journal of Veterinary Research Editorial Committee, Faculty of Veterinary Medicine, Hokkaido University
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