Efficacy of totarol against Staphylococcus pseudintermedius and Staphylococcus coagulans in dogs and cats

An in vitro study

Abstract

We investigated the susceptibility of totarol in 20 staphylococci strains, consisting of Staphylococcus pseudintermedius (n = 10) and S. coagulans (n = 10), from dogs and cats with skin infections. Each species contained 5 methicillin-resistant and 5 methicillin-susceptible strains. The minimum inhibitory concentrations (MICs) of totarol were determined by microbroth dilution method. As a result, all strains had the MIC of 4 μg/mL, except for one methicillin-susceptible S. coagulans strain, which had the MIC of 40 μg/mL. These MICs were extremely lower than the totarol concentration in commercially-available topical products. The present findings would support the use of totarol-containing topical products as one of the treatment options for canine and feline skin infections with both methicillin-susceptible and -resistant staphylococci.