Oxidative stress markers in dogs

A comparison between intact and gonadectomized individuals

抄録

This study measured serum or plasma levels of reactive oxygen metabolites (d-ROMs), biological antioxidant potential (BAP), and oxidative stress index (OSI) in dogs. The subjects were classified into four groups according to sex and gonadal status: intact males, castrated males, intact females, and spayed females, both off-therapy and during therapy. No significant differences were observed in d-ROMs, BAP, or OSI between the off-therapy and during therapy groups. Among off-therapy dogs, intact males showed significantly higher mean d-ROMs and BAP values compared with females and neutered dogs. In contrast, among during therapy dogs, no significant differences were found in d-ROMs among the groups; however, intact males had significantly higher mean BAP values than castrated males, and the OSI was significantly higher in castrated males than in intact males. These results suggest that gonadectomy in male dogs may influence the balance between oxidative and antioxidative processes through factors such as sex hormones. The findings highlight the importance of considering the effects of spaying and neutering when establishing reference values for oxidative stress markers in dogs.