2011 Volume 16 Issue 1 Pages 29-32
The era has been coming when antibiotics overuse is often seen in infectious diseases therapy for animals as well as human. It leads to increase of resistant bacteria to antibiotics, which become a threat to their environment and life. The proper use of antibiotics is the critical element for clinical efficacy, few side effects, and prevention from development of antibiotic resistance. Nowadays, design of antibiotics therapy is based on pharmacokinetics and pharmacodynamics theory which stands for parameters including Cmax/MIC for aminoglycosides, AUC/MIC for fluoroquinolones, and time above MIC for beta-lactams. A new therapeutic design of two-step infusion is expected for clinical efficacy and prevention for resistant bacteria.
