The author has formerly discussed in this journal on some fundamental problems on the clinical use of antibiotics. This time, he states on the practical principles of chemotherapies, obtained from his clinical data of several major internal diseases, i. e. sepsis, pneumonia, lung suppuration, and cholangitis.
Cases of these diseases were examined for the effects of therapy, and statistically observed to enumerate the most effective drugs for each disease. The in vitro sensitivity tests on the causual bacilli were found to be of some significance in the sepsis cases. For patients with lung suppurations, intratracheal injections of penicillin were more effective than ordinary administration, especially when streptomycin was combined with penicillin. In the cholangitis cases, inc coincidence of clinical and experimental conclutions on the marked efficacy of chloramphenicol was confirmed.
These findings of the author may be useful for the proper selection of chemotherapeutics in the practice of internal medicine.
