マウスのヒスタミン感受性に及ばす百日咳ワクチンの影響に関する研究(第1報)

抄録

The sensitivity of mice to Histamine following injection of hemophylus pertussis phase I cells markedly increases as has already been reported by Parventjev and Goodline.
By heating 100°C 30 minutes the histamine-sensitizing property of the pertussis vaccine was remarkably reduced, although there remained a little.
It was found that H. parapertussis, H. bronchosepticus, and phase variants of H. pertussis do not show the histamine sensitizing effect.
Anaphylactic sensitivity of mice to foreigne protein (as goat serum) was evidently increased by the pertussis vaccine injection as well as the histamine sensitivity.
It seems that the diphtheria toxoid can diminish the histamine sensitivity of pertussis vaccinated mice.
It was found that the differnce of sex and body weight had not influence upon the sensitivity in case of the same strain of mouse.
The histamine sensitivity was remarkably increased when H. pertussis was infected to the mice through the nasal route.
The zyramine sensitivity on mice was not changed by the pertussis vaccination.