Purine誘導体の凝血促進作用について(続)血球増多作用

抄録

The authors have reported that the platelet and leucocyte number in the peripheral blood of normal rabbits increased obviously by the administration of adenine, and it has been discussed that adenine acted on bone marrow chiefly and drove out neutrophils to the blood. In this paper it was observed the influence of adenine, theophylline and xanthine on the decrease of the leucocyte number after acute bleeding with the following results.
1) In normal rabbits the leucocyte number decreased by the acute bleeding ( 10 cc. per Kg. ) from the heart, and it minimized after 1 to 2 hours and returned gradually to the initial level after 3 to 5 hours.
2) By the administration of adenine or theophylline, the decrease of the leucocyte number of rabbit after bleeding did not occurred, or did transiently followed by the obvious increase.
3) Xanthine did not influence on the decrease of the leucocyte number after the acute bleeding. Thease results showed that adenine or theophylline increased the leucocyte number in the peripheral blood of the rabbits after the acute bleeding as markdly as in normal rabbits.