重症肺結核に対するスルファイソミヂン・INH療法(特に血液像に及ぼす影響)

抄録

Recently, sulfonamides plus INH has been recommended for pulmonary tuberculosis therapy.
This study comprised 10 cases of severe pulmonary tuberculosis. Patients were treated daily with 0.3 gm. of INH. and 2 gm. of sulfisomidin for 6 months. The results were as follows:
1) Body temperature, bo d y weight, blood-sedimentation rate, cough, sputum and appetite were improved at one month, and in no case was there any aggravation of symptoms during the period of chemotherapy.
2) Tubercle bacilli in the sputum b ecame negative in one patient and was reduced in one patient.
3) The chest roentgenogram showed improvement in 2 patients with infiltration and in one patient with cavity.
4) Blood picture:
a) Anemia improved and hemoglobin reached normal levels at 4 months, the reticulocyte count (below 6 ‰) which had been increased to above 10 ‰ in many patients, and color index (between 0.8 and 1.1.) had not been changed.
b) In the cases with leucocyte count below 5,000 and neutrophil count below 3,500, the former rose to above 5,000 and the latter to above 3,500 at 3-4 months. In no case did the leucocyte count or the neutrophil count fall. There was a marked shift to the left at the start of treatment, but this had returned to normal at 4 months. The ratio of neutrophils to lymphocytes decreased from 3.0 to 1.0 at about 5 months, and showed relative lymphocytosis.
c) There was tendency for the th r o m bocyte count to increase.
5) The abnormalities in the Cobalt R, Cadmium R, and B. S. P. tests showed a tendency to return to normal after 4-5 months.