Influence of Myleran on the Blood Picture of Rabbits

Abstract

Adult rabbits of each 2.5 kg body weight were treated with daily intraperitoneal injecof “Myleran” (I,4-dimethylsulonyloxybutane). The dosage schedules were as follows:
Group 1) 1 km/kg×12 days.Group 2 5 mg/kg×days. Group 3) 50 mg/kg×days. The blood and bone marrow pictures of the rabbits were observed.
Group 1). Leucocyte count was slightly increased, while, in the bone marrow, immature granulocytes were a little decreased. No particular changes were found in the other blood elements.
Group 2). Red cell count and hemoglobin content weres lightly decreased, while reticulocyte and thrombocyte counts were rather increased. Leucocytes, especially granulocytes, were decreased after a slight increase in the earlier stage. Bone marrow pictures showed a disturbance of the granulocyte formation.
Group 3). The red cell system of this group showed the similar changes as the group 2., while the leucocyte count increased remarkably. In the bone marrow, immature granulocytes were increased.
Therefore, myleran supresses mildly the granulocyte formation; but the latter seems to be stimulated by a large dosage of the drug.