The Journal of Kansai Medical University

On the Medical Care for the Tuberculous and Rehabilitation in the Minor Enterprises

Toshio Higashida, Michiko Tanaka, Hidetoshi Ishii

1959 Volume 11 Issue 4 Pages 589-593
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_589

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A study is made of the medical care on social medical insurance basis for 658 tuberculous workers engaging in minor enterprises for 2-4 years on mass examinations, the speciail reference to rehabilitation of the tuberculous. The results obtained are as follows:
1) About 70 per cent are treated with chemotherapy and 4 per cent with surgical treatment. The periods of chemotherapy for the most cases are short; less than 6 months for 28 per cent of the patients, less than one year for 50 per cent of them.
2) Forty per cent of the patients are away from work after the examination. Fifty per cent of the patients return to work after 6 months'rest.
3) Thirty per cent of the reposed lose their occupations. Half of the 30 per cent are due to “tuberculosis”. Twenty per cent of the reposed are out of work and 30 per cent are looking for jobs.
4) About 70 per cent of the offices and factories have regulations for sick leave, which, however, allow a very short period mostly less than a year. It seems that more facilities on a medical administration and social insurance basis are necessary in taking care of the tuberculous among the workers in medium and minor enterprises.

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The Dynamic Analysis of Maximal Expration Curve

Tatsuya Ikegami

1959 Volume 11 Issue 4 Pages 594-597
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_594

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1) It is theoretically shown that in the maximal expiration the speed of expiration gas is calculated by the following equation.
2) According as this equation several forms of maximal expiration curves are discussed.
3) The typical curves out of clinical cases are demonstrated.
(This Report was read at the 82 nd Meeting of Kinki Association for Surgery.)

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A Supplementary Report on Histochemical Findings of Bile Pigments

Ryuei Maeda, Reiko Takada

1959 Volume 11 Issue 4 Pages 598-606
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_598

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A study is made of toxic jaundice due to phenylhydrazine and toluylenediamine. The dried serum specimen of such experimental jaundice is histochemically tested on principle of Gmelin's or Hammarsten's reaction to a differentiation between direct-reacting bilirubin and indirect-reacting bilirubin. It is supported to conclude that the differences in reaction between these two types may lie in the differences in their entity, i. e., chemical constructure, rather than in the mere quantity of constituents in the serum or of bilirubin.

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The Origin of "Efferent Sympathicus via Posterior Root" in Bullfrog's Qblongate Medulla

Kaichi Kotsuka, Hiroe Naito, Shizuka Horikawa

1959 Volume 11 Issue 4 Pages 607-612
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_607

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1) It is demonstrated on a temporarily designated “carmin nicotine microinjection method” that the vasodilator fibers of “efferent sympathicus via posterior root” (kotsuka.1955)in bullfrog's tongue have their own origins in the oblongate medulla.
2) It is confirmed on a “carmin nicotin microinjection method” that the vasoconstrictor fibers of sympathicus via anterior root (Langley) have their own origins in the oblongate medulla.
3) The results of 1) and 2) support to conclude that there exist two functionally separate vasomotor origins, i. e., a vasodilator origin of “sympathicus via posterior root” and a vasoconstrictor origin of sympathicus via anterior root in bullfrog's oblongate medulla.

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Studies on Cardiac parasympathetic Function Part 4. The Effect of Vagal Cardio-Accelerating Actions on the Action Potentials of the Bullfrog's Heart.

Kaichi Kotsuka, Hiroe Naito

1959 Volume 11 Issue 4 Pages 613-617
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_613

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1) Action potentials of atropinized bullfrog's heart are increased when the peripheral cut ends of vagus nerves are stimulated within the cranial cavity on a new “glycerine spot method” (Kotsuka,1952).
It is demonstrated electrophysiologically that there exist efferent cardioaccelarator fibers in a bullfrog's vagus nerves.
2) The height of action potentials of the normal bullfrog's heart is decreased when the peripheral cut ends of vagus nerves are stimulated within the cranial cavity on a new “glycerine spot method” It is evidenced electrophysiologically that the heart of bullfrogs is subjected to a “parasympathetic double efferent innervation”.
3) It is revealed electrophysiologically that there is no qualitative difference between efferent vagal cardio-accelerator effects and sympathetic cardio-accelerator effects of bullfrogs.

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On the Vasodilator Action of Efferent "Sympathicus via Posterior Root. "

Shizuka Horikawa

1959 Volume 11 Issue 4 Pages 618-646
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_618

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On the Accessory Vasodilator Nerves and Their Cell Stations of Bullfrogs

K. Kotsuka, H. Naito, M. Yamada, F. Matsuda

1959 Volume 11 Issue 4 Pages 647-651
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_647

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1) The small arteries in a bullfrog's tongue are dilated when the peripheral cut ends of accessory nerves are stimulated within the cranial cavity on a new “glycerine spot method” (Kotsuka,1952). It is evidenced therefore that there exist the efferent vasodilator fibers in a bullfrog's accessory nerves.
2) It is demonstrated with physiological evidence on a new “glycerine spot method” and the nicotine method (Langly and Dickinson) that the vasodilator fibers of accessory nerves have their cell stations in the spinal ganglia (I).
3) Concerning to a bullfrog, it seems that accessory nerves are equivalent in terms of vasomotoric function posterior root of spinal nerves.

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The Origin of Hypoglossal Vasoconstrictor Nerves and of Accessory Vasodilator Nerves in the Bullfrog's Oblongate Medulla

Kaichi Kotsuka, Hiroe Naito, Michico Yamada, Fumi Matsuda

1959 Volume 11 Issue 4 Pages 652-657
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_652

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1) It is demonstrated on a temporarily designated “carmin nicotine microinjection method” that the hypoglossal vasoconstrictor fibers of bullfrog's tongue have their own origin in the oblongate medulla.
2) It is revealed on a “carmin nicotine microinjection method” that the accessory vasodilator fibers of bullfrog's tongue have their own origin in the oblongate medulla.
3) The results of 1) and 2) support to conclude that there exist two functionally separate vasomotor origins i. e., hypoglossal vasoconstrictor origin and accessory vasodilator origin in bullfrog's oblongate medulla.

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Studies on the Pigment Production of Pseudomonas Aeruginosa. (5th Report) Cooperative Effects of Sugars and Amino Acids on the Pigment Production.

Setsuo Kan

1959 Volume 11 Issue 4 Pages 658-669
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_658

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Studies are made on various factors effectively influencing the production of fluorescin, pyocyanin and melanin of Pseudomonas aeruginosa as well as the productive aspethereof, with the following results:
1) A slant agar medium consisting of a synthetic medium added by 0.3-0.5% peptone is found to be very favorable in determining the kinds of the pigments which Pseudomonas aeruginosa produces. During the determination, fluorescin is diffused over the medium, melanin is observed on the uppermost layer of the medium, and pyocyanin is found on the next lower layer as a band.
2) Four sugars, glycerol, glucose, fructose and mannit in various combinations are studied as to their effects on the pigment production of Pseudomonas aeruginosa. It is revealed that each pigment is referable to its specific amino acid and that each combination of sugars results in its specific productive aspects.
3) Numerous amino acids uniformly take part in the production of fluorescin and melanin; only a small number of amino acids does in the production of pyocyanin.
4) No amino acids or sugars considered essential for the production of pigments are scarcely observed. But many amino acids and sugars are found to participate in the production rather favorably. The degree of such favorable participation is dependent upon the conditions under which sugars and amino acids are combined.
5) What is considered to belong to pyocyanin strain and what is considered to belong to melanin strain are possessed with the ability of producing pyocyanin, melanin, and fluorescin. It seems that only in the amount of pigment production the former is different the latter. It is obvious that the amount is influenced to some extent by the environmental conditions under which these strains grow.

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Serological studies on the crawfish (Cambarus clarkii) On the cellular reaction in an epithelial membrane under the wastocardiac region of its shell

Shinobu Osawa, Emiko Inoue, Eiko Kurimoto, Nobuko Matsui, Setsua Kan

1959 Volume 11 Issue 4 Pages 670-674
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_670

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Studies are made of the crawfish (Cambarus clarkii) as to the epithelial membranous tissuses of the shell with special reference to the gastrocardiac region.
The epithelial membrane in this region contains vessel-like tissues and grouped globulous cells communicated with these tissues. The globulous cells, being 150-190μ in diameter, mostly spherical and occasionally irregular in shape, are 30 in number on an average. They attach to the apex where vessl-like tissues are arbolized or to the lateral well. They show an active proliferative reaction in response to antigenic substances administerd. The proliferated cells are differentiated into those of the same kind as blood cells. It is assumed that the epithelial tissues which contain the above globulous cells constitute a main hematopoietic organ of this animal.

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Reports on 2 cases of duodenal diverticulum with surgical corrections

Kimiko Kawanabe, Setsuo Kann, Kayoko Nakamura, Mariko Kido, Takaji Has ...

1959 Volume 11 Issue 4 Pages 675-680
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_675

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One of them was a case of great diverticulum which developed lateral to the pars descendens and of sack-form. This diverticulum was proved to be a real diverticulum pathologicohistologically.
The other case, not founded at the time of laparotomy, was founded during the reconvalescent period after the operation fluoroscopically.
The prognosis of these cases was good.

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Experimental studies on the Allergic Granulocytopenia

Toshiro Okuno

1959 Volume 11 Issue 4 Pages 681-714
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_681

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Rabbits, sensitized with human sera, were treated repeatedly with injections of the antigen to cause an allergic granulocytopenia.
Granulocytes almost disappeared from the peripheral blood of the rabbits 10-60 minutes after the shock injection, andthen,1-2 hours after the injection, a remarkable increase of the cells was observed, accompanied with the shift to the left of nuclei, appearance of degenerated cells and nucleous shadows. The granulocyte count decreased again in 24-48 hours and recovered to the normal level in 5-6 days.
By repeated shock injections, the granulocyte count kept a low level, which was not recovered to the normal at least 2 weeks after the last injection. In the bone marrow, nucleated cells, especially immature granulocytes, were remarkably decreased.
On the contrary, unsensitized animals showed neither shock syndrome, nor granulocytopenia after 3 times injections of human sera.
Red cell count, hemoglobin content and thrombocyte count also gradually came down accompanied with the allergic granulocytopenia. Increase of reticulocytes, appearance of erythroblasts in the peripheral blood and increase of polychromatic normoblasts in the bone marrow were also observed.

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Influence of Myleran on the Blood Picture of Rabbits

Toshiro Okuno

1959 Volume 11 Issue 4 Pages 715-724
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_715

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Adult rabbits of each 2.5 kg body weight were treated with daily intraperitoneal injecof “Myleran” (I,4-dimethylsulonyloxybutane). The dosage schedules were as follows:
Group 1) 1 km/kg×12 days.Group 2 5 mg/kg×days. Group 3) 50 mg/kg×days. The blood and bone marrow pictures of the rabbits were observed.
Group 1). Leucocyte count was slightly increased, while, in the bone marrow, immature granulocytes were a little decreased. No particular changes were found in the other blood elements.
Group 2). Red cell count and hemoglobin content weres lightly decreased, while reticulocyte and thrombocyte counts were rather increased. Leucocytes, especially granulocytes, were decreased after a slight increase in the earlier stage. Bone marrow pictures showed a disturbance of the granulocyte formation.
Group 3). The red cell system of this group showed the similar changes as the group 2., while the leucocyte count increased remarkably. In the bone marrow, immature granulocytes were increased.
Therefore, myleran supresses mildly the granulocyte formation; but the latter seems to be stimulated by a large dosage of the drug.

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One Case of Pulmonary Carcinoma obserbed from Begining to End in Our Hospital

Sen-ichiro Hashimoto, Ichiteru Shishioka, Hisako Takano

1959 Volume 11 Issue 4 Pages 725-731
Published: October 20, 1959
Released on J-STAGE: February 19, 2013

DOIhttps://doi.org/10.5361/jkmu1956.11.4_725

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