家兎耳殼湯傷に対する塩酸Procaine作用の実験的研究

抄録

It is a well known fact through literatures that there is a functional relationship between various disease symptom complexes and sympathetic nervous system, and although the disharmony or the disfunction of the sympathetics is not a causal factor of the diseases, the correction of the disintegrated function using procaine hydrochloride invites the relief or improvement at tnose symptom complexes.
To invesigate the action of procaine hydrochloride on scalds on rabbit's ear, the author have made the experiments with rabbits treated with 70°C. hot water for 5 minutes on their ears to figure out 1) the influence of procaine hydrochloride on the lesion.2) the amounts of effective, non-effective and toxic doses,3) the route of administration preferred to gain better effect, and 4) the frequency of the administration of the drug.
The results obtained are as follows:
1) Procaine therapy on scalds on rabbit's ear favors to prolong the formation of thrombi in affected vessels, and save the tissue from necrosis.
2) The action of procaine hydrochloride on scalds on rabbit's ear differs by the route of its administration. Intravenous administration of the drug is most effective than local block or sympathetic ganglion block.
3) There is no peculiar difference in its effectiveness among those to which the procaine therapy is performed immediately after and six hours after the scalds. Those, however, to which procaine therapy is instituted twelve hours after the scalds shows less effectiveness in saving the affected tissue from necrosis. Repeated injection every twenty-four and seventytwo hour intervals does not influence to the disease process.
4) Effective dose of procaine hydrochloride on scalds on rabbit's ear shows 4-6mg., non-effective dose less than 2mg. and toxic dose 18.1-33.2 mg. per kilogram of body weight in average when administered intravenously.