関西医科大学雑誌
Online ISSN : 2185-3851
Print ISSN : 0022-8400
ISSN-L : 0022-8400
ペニシリューム脳内接種マウスのペニシリン過敏性獲得に関する研究補遺
西尾 義輝
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ジャーナル フリー

1961 年 13 巻 1 号 p. 148-164

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1. Hypersensitiveness against penicillin was snccessfully acquired upon the mice by means of inoculating a quantity of vital penicillium, its protoplasma or cell polysaccharide into the encephalons of mice.
2. It conld be proved that acquiring hypersensitiveness against peniciellin should also be occurred by inoculating certain amounts of another strain of penicillium which isolated from rice-cake or of Trychyton ruburum isolated from the human nail trychophytia.
3. In this studyp the most remakable acquirment of hypersensitiveness was generally occurred at the 20th day after sensibilization.
4. It could be recognized that the desensitization by PcG was slightly occured upon the mice intraencephalicaly inoculated penicillin, but not a perfect one. This was, however, reinstated in some days after desensitizing treatment, and hypersensitiveness was maintained for considerably long space of time.
5. Unexpecten side effects by the toxicity of penicillin were inhibited by the relaxant for the autonomic nurve or the adrenal cortical hormone, especially, the latter was effective.
6. Penicillinase decomposed penicillin, but is was not expected to prevent penicillin-shock.
7. It was not able to acquire the hypersensitiveness by means of the intraperitoneal sensibilizing technic with the emulsion of mouse brain and the penicillium.
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