抄録
In the present paper, the migrations of hemolysin plaque forming cells (HPFC) contained in the spleen were made 24 hours apart during ten days according to Jerne's method after the primary sensitization of sheep erythrocyte antigen (SEA), and in that corse, especially, the mutual relation in quantity-- on the one hand between formation of HPFC and of pyruvate, lactate, acetaldehyde, inosine (antibody promoting factor), uric acid, and on the other hand. -- NADH activity contained in the mouse spleen was examined, and the results obtained were as follows:
The formation of HPFC increased in quantity about 2 times 24 hours later and arrived to a maximal value 4-5 days later after the SEA invasion, i. e. it corresponded to about 240 times of non-treated control group in quantity and after that, it decreased abruptly to normal range in quantity in the mouse spleen. Both lactate and uric acid increased similarly and arrived to a maximal value 1-2 days before HPFC and on the contrary, inosine increased parallel to the behavior of HPFC daily, and pyruvate and acetaldehyde had almost no behaviour. The simple or combined pre-treatments of inosine and pyruvate into the peritoneal cavity for 7 days prior to the sensitization of SEA remarkably accelerated to about 2-3 times the HPFC formation as compared with non-pretreated control group, respectively.
