1969 Volume 21 Issue 3 Pages 67-75
Early morphological changes on the ovary of the mice of C3H and A/Jax strains were observed in the course between 1 day and 3 months after the single injection of 7,12-DMBA, in order to investigate why C3H mice are favorate to the ovarian tumorigenesis by 7,12-DMBA but A/Jax mice are resistant to it.
The weaker lipid-reaction was recognized on thec a interna and interstitial gland of the ovarian tissue in both strains several days after the administration. The degeneration and necrosis of oocytes and stronger activity of dehydrogenases in interstitial gland of the ovaries were also detected thereafter. Two weeks later, disappearance of oocytes, degeneration of some granulosa cells and cystic formation in ovarian follicles were revealed in both strains. In the injured ovaries, follicular structures were destroyed and almost all oocytes vanished within 1 month. Corpora lutea were degenerative. Interstitial tissue of the ovarian tissues was loose edematous and of different degree of luteinization. Finally, the damaged ovaries revealed a histioid structure 1 - 2 months after the injection of 7,12-DMBA. Such a histioid structure was not so different from each other in the both strai ns examined at the 2nd month. But, the damage in the interstitial gland was more severe in the mice of C3H strain.
Nodules of small atypical cells, resemble to the granulosa cells, were detected only in the mice of C3H strain 3 months after the treatment.
