Experimental Studies on Ovarian Tumorigenesis
Part 3. Effect of 7, 12-DMBA upon Sensibility of Ovarian Tissues to Gonadotrophin in Mice of C3H and A /Jax Strains
1969 Volume 21 Issue 3 Pages 76-83
Details
1969 Volume 21 Issue 3 Pages 76-83
On the mice of C3H and A/Jax strains at the age of 6 - 7 weeks, the sensibility of the ovarian tissues to gonadotrophins was investigated 4 days after the single intravenous injection of emulsion of 7,12-DMBA (2.5 mg).
By means of Brown's bioassay method f or LH, the sensibility to LH was distinctly proved on the ovary of 80% of control mice of both strains. It was just recognized on the ovary of 30% of DMBA-treated mice of C3H strain, and in 60 % of DMBA-treated mice of A/Jax strain.
According to Lloyd's bioassay method for FSH, the ovaries of DMBA-injected mice of both strains lost prominently the sensibility to FSH.
The above-mentioned functional damages in the o varian tissues induced with 7,12-DMBA just 4 days after the single injection and the strain-difference upon them indicated that the injury in specific interstitial cells of the ovary would be essential to the ovarian tumorigenesis by the carcinogen in mice.
