1969 Volume 21 Issue 3 Pages 84-98
For the purpose of examining the carbohydrate metabolism in pregnancy, the existence or otherwise of glucosuria was adjudged in Hema Combistix in 2891 cases of pregnant women, and, in 371 positive cases, of which glucose tolerance test (GTT) and cortison glucose tolerance test (CGTT) were performed.
As a result, it became apparent that most of them had a disorder of renal glucosuria, which was ascertained to conspicuously increase after six months of the pregnancy or in the middle part of the pregnancy, making its appearance in the majority of cases during the latter half of the pregnancy.
Also, at the time of initial period of glucosuria, it was found, it similarly increases conspicuously in the latter period of the pregnancy.
While it is known that those pregnan t women who have an onset of diabetes during pregnancy are highly prone to develop such obsterical complications as the delivery of gigantic babies, toxemia of pregnancy, still-birth, etc., the result obtained indicated that, in such pregnant women who developed obsterical complications, the percentage of such abnormalities was similarly high also in GTT and CGTT. Particularly high was the percentage of abnormalities of GTT and CGTT in the case of such women who had just delivered gigantic babies. It would accordingly seen necessary that these pregnant women be placed under a close observation over a substantial period of years.
Moreover, such pregnant women with obesity above +10.0%, carrying factores of diabetic heredity, were seen to indicate conspicuously high percentages of abnormalities also of GTT and CGTT. Also, in case of such pregnant women, whose serum insulin carried factors of diabetic heredity and with obesity above +10.0%, both GTT and CGTT were found to have exceedingly high percentages of abnormalities.
Those pregnant women, who were found to carry the factors of diabetic heredity also in serum insulin were seen to demonstrate a delayed type insulin reaction reminiscent of an initial diabete or a slight case of diabetes.
In the light of these results obtained, it has been made clear that, by examining the carbohydrate metabolism and obstetrical complications in pregnancy, an onset of diabetes may, in the future, be predicted at an early stage, and that, in this sense, such examinations are of great significance.
