Strophanthin-G Toxicity and Influences of Trimetazidine on Actions of Strophanthin-G on Guinea-pig Atria

Abstract

On the strophanthin-G toxicity and influences of trimetazidine on it, changes of inorganic ions content in isolated guinea-pig atria were examined.
1) The strophanthin-G toxicity was marke dly reduced in a low sodium medium and it was increased in a low potassium medium.
2) A potassium-free medium or a toxic dose of strophanthin-G caused a decrease in potassium content and an increase in sodium content in atria.
3) Trimetazidine prevented a decrease in potassium c ontent but could scarcely prevent an increase in sodium content in atria kept in a normal Locke's solution containing strophanthin-G in a toxic dose.
4) Trimetazidine may reduce strophanthin-G toxicity perhaps through inhibiting the efflux of atrial potassium.