Effects of Quinidine and Thiamine tetrahydrofurfuryldisulfide on Electrocardiogram of Rabbit

Abstract

Quinidine and thiamine tetrahydrofurfuryldisulfide (TTFD) were investigated for their effects on ECG of rabbit in relation to interaction of these drugs. The QRS complex, P-Q interval and Q-T interval were prolonged after the intravenous injection of 17.5mg/kg of quinidine. TTFD injected intravenously in doses of 10 to 20 mg/kg prolonged R-R interval for 2 to 3 hours and depressed sinus node activity for 1 to 5 minutes. Premedication of TTFD in above doses reduced changes of QRS complex and P-Q interval caused by quinidine.