Influence of dietary protein on gastric tumorigenesis by N-methyl-N ' -nitro-N-nitrosoguanidine in rats

Part I Influence of various proportion of casein diets on gastric tumorigenesis

抄録

The proportion of dietary protein modifies the tumorgenesis of glandular stomach in rats that received NG in drinking water. If a 50% casein diet is given regularly from the date of carcinogenic stimulus by NG, the final tumor number and their malignancy are more pronounced than in other groups maintained on 20% or 36% casein diets.36% casein diets, when given concurrently with the carcinogen throughout the experimental period, showed slightly more accelerated tumorgenesis than rats on 20% casein diets, but there were about the same number of malignancies. The survival time of rats on 5 % casein diets was too short and no tumors developed among rats that survived 5 to 6 monthes after experimental initiation.
The general conclusion drawn from these data is that high dietary protein exerts a potentiation effect on NG tumorgenesis, especially in carcinogenesis.