AminopyrineとBarbiturateの併用作用に関する研究(第1報)

Aminopyrineの解熱作用に及ぼすIsomytal-Naの影響

抄録

Antipyretic effects of aminopyrine, isomytal-Na and the various mixtures of these drugs were studied with fever rabbit by typhoid vaccine injected intraveneously. Aminopyrine 0.1 g per kg subcutaneously injected, dropped the temperature in rectum quickly and raised the temperature in ear skin; that is, the increased heat radiation from skin was important for the development of the antipyretic effect of aminopyrine.
Isomytal-Na 0.05 g per kg subcu taneously injected, had also antipyretic action and in this dose the anesthetic action was observed.
The antipyretic effect of isomytal-Na was more slowly developed than that of aminopyrine, perhaps due to depression of heat radiation and seemed therefore, to be secondary effect of it's anesthetic action. The antipyretic effect of aminopyrine was d ecreased by concomitant administration of various doses of isomytal-Na, by which heat radiation from skin was remarkably depressed. On the other hand, anesthetic effect of isomytal-Na was depresseed slightly by administration of aminopyrine 0.1-0.05 g per kg. From above results it may be considered that aminopyrine and isomytal-Na are antagonistic in the action on the vasomotor of heat regulating center.