抄録
CD83 has been known for a decade to be one of
the best markers for mature dendritic cells (DCs).
The recognition of CD83 was greatly changed
since CD83 in thymus was unveiled to be essential
for the generation of CD4+ T cells by the study
using CD83-deficient mice. It was recently shown
that both activated DCs and B cells release soluble
form of CD83 and that low levels of soluble CD83
are present in normal human sera. Both in vivo and
in vitro studies demonstrated that soluble CD83
has immunosuppressive roles such as the inhibition
of DC-mediated T cell stimulation and the
maturation of DCs. CD83 appears to have regulatory
functions for immune response in light of
observations that the soluble form of CD83 can
inhibits immune reactions while being strongly
up-regulated during DC maturation and activation.
In addition, the fact that various cell types including
thymic epithelial cells, activated T and B cells and
activated DCs express CD83 suggests the universal
role in immune function. Because of these
immuno-regulatory functions, the therapeutic
application of CD83 is highly anticipated in many
pathological states including malignancy and
autoimmune disease.
