Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus

Yanfei Hou; Mutsumi Nakahashi; Kazuaki Mawatari; Takaaki Shimohata; Takashi Uebanso; Yumi Harada; Akari Tsunedomi; Takahiro Emoto; Masatake Akutagawa; Yohsuke Kinouchi; Akira Takahashi

doi:10.2152/jmi.63.63

Originals

Combined treatment of UVA irradiation and antibiotics induces greater bactericidal effects on Vibrio parahaemolyticus

Yanfei Hou, Mutsumi Nakahashi, Kazuaki Mawatari, Takaaki Shimohata, Takashi Uebanso, Yumi Harada, Akari Tsunedomi, Takahiro Emoto, Masatake Akutagawa, Yohsuke Kinouchi, Akira Takahashi

著者情報

Yanfei Hou
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Mutsumi Nakahashi
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Kazuaki Mawatari
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Takaaki Shimohata
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Takashi Uebanso
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Yumi Harada
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Akari Tsunedomi
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School
Takahiro Emoto
Department of Electrical and Electronic Engineering, Institute of Technology and Science, Tokushima University Graduate School
Masatake Akutagawa
Department of Electrical and Electronic Engineering, Institute of Technology and Science, Tokushima University Graduate School
Yohsuke Kinouchi
Department of Electrical and Electronic Engineering, Institute of Technology and Science, Tokushima University Graduate School
Akira Takahashi
Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School

キーワード: UVA, LED, bactericidal effect, synergistic benefit, antibiotics

ジャーナルフリー

2016 年 63 巻 1.2 号 p. 63-67

DOI https://doi.org/10.2152/jmi.63.63

詳細

抄録

The presence of antibiotics in the environment and their subsequent impact on the development of multi-antibiotic resistant bacteria has raised concerns globally. Consequently, much research is focused on a method to produce a better disinfectant. We have established a disinfectant system using UVA-LED that inactivates pathogenic bacteria. We assessed the bactericidal efficiency of a combination of UVA-LED and antibiotics against Vibrio parahaemolyticus. Combined use of antibiotic drugs and UVA irradiation was more bactericidal than UVA irradiation or antibacterial drugs alone. The bactericidal synergy was observed at low concentrations of each drug that are normally unable to kill the bacteria. This combination has the potential to become a sterilization technology. J. Med. Invest. 63: 63-67, February, 2016

責任著者(Corresponding author)

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