2026 年 73 巻 1.2 号 p. 55-61
Background:It remains to be elucidated that the differences in treatment effects on allergic rhinitis (AR) symptoms and quality of life (QOL) in patients with Japanese cedar (JC) pollinosis during different pollen dispersal seasons. Objectives:We compared the effects of sublingual immunotherapy (SLIT) with JC pollen tablets and prophylactic treatment with antihistamines on AR symptoms and QOL during different JC pollen dispersal seasons. Material and Methods:106 and 129 patients with JC pollinosis were enrolled during the small and large JC pollen dispersal seasons, respectively. They were categorized into the SLIT, antihistamine, and untreated groups. AR symptoms and QOL scores were evaluated. Results:The SLIT group showed significant improvement in all AR symptoms and QOL scores compared with the untreated group during both the small and large pollen dispersal seasons. The antihistamine group showed significantly improved nasal symptoms and higher QOL scores than the untreated group during the small pollen dispersal season, but it did not show any improved QOL scores, during the large pollen dispersal season. Conclusions:These findings suggested that JC pollen SLIT was more effective in suppressing AR symptoms than prophylactic treatment with antihistamines, resulting in improved QOL during the large JC pollen dispersal season. J. Med. Invest. 73 : 55-61, February, 2026
