Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Lecture Notes
Tumor Immunology
Principles and Translations
HIDEO YAGITA
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2014 Volume 60 Issue 4 Pages 358-361

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Abstract

Recently, immune checkpoint blockade with anti-CTLA-4 and anti-PD-1 antibodies has the greatest impact on clinical cancer therapy. The rationale for these therapeutic regimens has been established by our advanced knowledge about basic immunology, such as the identification of tumor antigens and the elucidation of self-tolerance mechanisms, and proof-of-concept experiments in animal models. More applications of the immunostimulatory antibodies targeting costimulatory molecules, such as CD40 and CD137, and coinhibitory molecules, such as TIM-3 and VISTA, are now expected. Accumulating evidence shows that these immunostimulatory antibodies can be successfully combined with conventional chemotherapy and radiotherapy to improve their efficacy.

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