Peking University - Juntendo University Joint Symposium on Brain and Skin Diseases

Rare Fungal Infections: What Should We Know?

Abstract

Rare fungal infections sometimes are recalcitrant and life-threatening, which bring a big challenge to the clinical management. Recent studies of chronic mucocutaneous candidasis, deep dermatophytosis and some dematiaceous fungal infections have led to many breakthroughs in our understanding of host defense against fungal infections. This review summarizes important findings, including the author’s recent work, of crucial mechanisms that predispose some rare cutaneous fungal infections, including Dectin-1 deficiency, CARD9 deficiency, and STAT1 gain-of-function mutations.