2016 年 62 巻 4 号 p. 315-317
Deep brain stimulation (DBS) is a surgical procedure to treat motor symptoms in Parkinson disease (PD). DBS modulates neurological function of the target region using implanted medical devices to deliver electrical stimulation to the brain. The most common target for PD is the subthalamic nucleus (STN). STN DBS improves motor function in the medication-off state, motor fluctuations and dyskinesia with reduction of dopaminergic medication. Long-term outcomes are favorable for cardinal motor symptoms. However, refractory axial symptoms concerning speech, swallowing, gait and postural stability gradually deteriorated with progression of disease. New strategy to treat these axial symptoms is the future subject.
