Poster Sessions - Musculoskeletal System
Effects of Treadmill Running on Bone Density and Bone Strength in Young Mice
2016 年 62 巻 Suppl.1 号 p. 181-185
詳細
2016 年 62 巻 Suppl.1 号 p. 181-185
Objective: To investigate the effects of treadmill running exercise on bone density and bone strength in young mice.
Methods: Four-week-old male C57BL/6 mice (n=10) were assigned to either the control sedentary group (CON, n=5) or the treadmill running exercise group (TRE, n=5). Mice in the TRE group were forced to run on a treadmill at a rate of 6-18 m/min, 30 min/day, 5 days/week for 16 weeks. The mice in both groups were euthanized at 20 weeks of age. The right and left lower limbs, skeletal muscle, and white adipose tissue were removed for analysis. Bone density (mg/cm 3) was measured in the right limb using microcomputed tomography, and maximal breaking force (N) was determined in the left femur using a three-point bending test as an indicator of bone strength.
Results: The TRE and CON groups did not significantly differ with respect to daily food intake during the study period or body weight at 20 weeks of age. Differences in white adipose tissue and skeletal muscle weight of 20-week-old mice in the TRE and CON groups were also not significant. Cortical bone density was significantly higher in the TRE group than in the CON group (p<0.05). However, there were no significant differences in cancellous bone density, total bone density or maximum breaking force between the TRE and CON groups.
Conclusions: Treadmill running exercise for 16 weeks can increase cortical bone density of tibia in young mice, but does not improve bone strength in femur.
