2016 年 62 巻 Suppl.1 号 p. 76
Background: Physical exercise has been reported as a preventive measure of Alzheimer's disease, one of the neuropathological hallmarks of which, neurofibrillary tangles, consist of hyperphosphorylated insoluble tau. Long-term treadmill exercise reduced tau hyperphosphorylation: however, it remains unknown whether short-term treadmill exercise alters tau modifications.
Aim: Here we attempted to characterize the effects of short-term treadmill exercise on tau solubility and determine its relationship with neuroinflammation using tauopathy model mice (Tg601).
Results: 3 weeks of non-shock treadmill exercise in Tg601 and non-transgenic mice markedly increased insoluble tau by increasing the phosphorylation at the tau C-terminal end, particularly at Ser396. The results of immunohistochemical analyses revealed that short-term treadmill exercise increased the number of Ionized calcium binding adaptor molecule-1 (Iba-1) positive microglia in the hippocampus. Elevations in the levels of the lipid peroxidation markers 4-hydroxy-trans-2-noneal and malondialdehyde indicated the presence of oxidative stress.
Conclusion: Our results suggested that short-term forced exercise was harmful rather than beneficial to Alzheimer’s pathology.
