Heat shock protein 27 (HSP27) is a multidimensional protein that acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in protective roles in various disease states. The current review presents HSP27 in multiple disease contexts, including neurodegenerative and cardiovascular diseases, highlighting its role as a potential therapeutic target.
