Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Original Articles
Cerebrospinal Fluid Matrix Metalloproteinase-9 Level in Children with Bacterial Meningitis
AYAKO TSUMITAKAORU OBINATASHIGEAKI INOUETOMOYUKI NAKAZAWAKENICHIRO KANEKOAKIHISA OKUMURATOSHIAKI SHIMIZU
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2017 Volume 63 Issue 1 Pages 29-33

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Abstract

Objective: Cerebrovascular impairment and secondary inflammatory responses are important in bacterial meningitis-associated brain damage. The purpose of the study was to evaluate matrix metalloproteinase-9 (MMP-9) as a marker for brain damage in bacterial meningitis.

Materials: The subjects were 31 pediatric patients, including 12 with bacterial meningitis, 12 with aseptic meningitis, and 7 with other infections of the central nervous system.

Methods: Several potential markers, including MMP-9 in cerebrospinal fluid (CSF), were measured in all the pediatric patients.

Results: Children with bacterial meningitis had a significantly higher level of CSF MMP-9 compared to those with other diseases aseptic meningitis and encephalitis/encephalopathy. CSF levels of MMP-9 in the 6 patients without complications markedly decreased in the recovery phase, while those of the 6 patients with complications remained high or re-elevated. CSF MMP-9 in the recovery phase was significantly higher (p<0.01) in patients with complications.

Conclusion: The CSF MMP-9 level may be a useful prognostic marker in pediatric patients with bacterial meningitis.

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© 2016 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.
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