2017 Volume 63 Issue 5 Pages 319-321
Integrins are heterodimeric transmembrane receptors that mediate cell-matrix adhesion and are essential for multiple cellular functions in eukaryotes including development and cancer progression. Integrins interact with extracellular matrices through their extracellular domain and interact with intracellular proteins thought their cytoplamisc tails. Integrins transduce chemical and mechanical signals across the membrane to maintain the homeostasis. Among the integrin-interacting proteins inside the cell, a group of FERM domain-containing proteins play a pivotal role in mediating integrin functions, especially in cancer progression. Here, the integrin-interacting FERM domain-containing proteins in regulation of cancer progression will be discussed.
