Abstract
What is written in genome? According to proposition since Watson - Crick Model was proposed for DNA structure: nucleotide sequence is the code source of the genome. However, we still do not understand what the real meaning of genome sequence consisting of four bases is, and what molecular mechanism beyond the development of individual organism from a fertilized egg is. Various sorts of proteins in our body are the final products of genome sequence in terms of classical central dogma, but protein is just a sort of the so-many products derived from the genome information. To understand “what is written in genome” , one need to analyze not only genome and proteome, but also all of other “omes” .
In this paper, we describe the history of the international Functional Annotation of the Mammalian Genome (FANTOM) consortium led by RIKEN for the past quarter century, to clarify the transcriptome, promotome, network and enhancerome. We argue that the FANTOM activity is a model of the from-now research style in life sciences.
© 2018 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.
