原著
Characteristics of Bone Metabolism in Middle-Aged and Older Mountaineers
2018 年 64 巻 4 号 p. 278-285
詳細
2018 年 64 巻 4 号 p. 278-285
Objective: This study aims to elucidate the characteristics of bone metabolism in middle-aged and older mountaineers and compare them with those who walk regularly and those who do not exercise regularly.
Materials: We enrolled 17 middle-aged and older mountaineers [Mountaineer Group; 8 males (age: 65.9±4.5 years) and 9 females (age: 60.4±5.5 years)], 20 people who walked regularly [Walker Group; 10 males (age: 67.5±5.2 years) and 10 females (age: 63.2±5.7 years)], and 17 people with sedentary lifestyle [Control Group; 9 males (age: 67.3±5.2 years) and 8 females (age: 62.7±4.9 years)] in this study.
Methods: All assessments in this study were based on the osteo sono-assessment index (OSI) and bone metabolism markers. We used bone alkaline phosphatase (BAP) and procollagen type 1 aminoterminal propeptide (P1NP) as bone formation markers. In addition, we used tartrate-resistant acid phosphatase 5b (TRACP 5b) and type I collagen cross-linked N-telopeptide in serum (sNTX) as bone resorption markers.
Results: There was no significant difference in OSI among the three groups in males and females. In addition, there was no significant difference between BAP and P1NP in males. The TRACP-5b level was significantly higher in the Mountaineer Group (459.5 mU/dl) than in the Control Group (333.0 mU/dl; p<0.05) in males. In addition, there was no significant difference in the bone formation/resorption ratio among the three groups in males. In females, there was no significant difference in each bone metabolism marker among the three groups.
Conclusions: Middle-aged and older males who mountaineer regularly had higher resorption than those who do not exercise regularly, but there was no difference in coupling. Furthermore, there were no prominent traits in the bone metabolism of middle-aged and older females who mountaineer regularly.
