Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Poster Sessions - Life Style and Cardiovascular System
Slightly Elevated BMI Within Normal Limits at Young Age Predict Metabolic Disorders in Japanese Men
YUKI SOMEYAYOSHIFUMI TAMURAYOSHIMITSU KOHMURAKOSUKE FUKAOKAZUHIRO AOKISACHIO KAWAIHIROYUKI DAIDA
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JOURNAL OPEN ACCESS

2018 Volume 64 Issue Suppl.1 Pages 40

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Abstract

Background: Obesity and associated metabolic disorders are rapidly increased all over the world. However, metabolic syndrome and cardiovascular disease (CVD) are easily developed in Asian adults with normal body mass index (BMI), compared with BMI matched other ethnicities. Thus, slightly increased BMI level (>23 kg/m2) in adults is recognized as a risk for development of metabolic disorders and CVD in Asians. However, to date, it has not been investigated whether small increase in BMI level at young age is also a risk factor for development of metabolic disorders later in life in Asians.

Purpose: To investigate the impacts of BMI at young age on development of metabolic disorders (hypertension, diabetes and dyslipidemia) later in life in Japanese men.

Methods: The study subjects are male alumni who were graduated from Juntendo University from 1971 to 1991. From 2007 to 2011, a self-administered follow-up questionnaire was sent by mail to the subjects to ask their previous medical diagnosis of metabolic disorders, including hypertension, diabetes and dyslipidemia. This study included subjects with both BMI at the time of college and returned follow-up questionnaire were available. Then, we categorized the study subjects into quartile (Q1, Q2, Q3 and Q4) by BMI and compared the incident of metabolic disorder by Cox proportional hazards models.

Results: This study analyzed 636 male alumni and covered 26-year follow-up period (Interquartile Range: IQR: 22-30 years) that included 16,395 person-years of observation. The median BMI at young age of categories were Q1: 20.4 kg/m2 (IQR: 19.7-20.8 kg/m2), Q2: 21.6 kg/m2 (IQR: 21.3-21.8 kg/m2), Q3: 22.5 kg/m2 (IQR: 22.3-22.7 kg/m2) and Q4: 24.0 kg/m2 (IQR: 23.4-25.1 kg/m2). During the period, 194 men had developed more than one metabolic disorder. The prevalence rates of more than one metabolic disorder in Q1 to Q4 were 23.9%, 25.8%, 35.6%, and 36.7%, respectively (p=0.02) and their hazard ratios were 1.00 (reference), 1.21 (IQR: 0.78-1.89), 1.76 (IQR: 1.16-2.67) and 1.82 (IQR: 1.21-2.76), respectively (p=0.001 for trend). This trend was similar after adjustment for age, smoking and participation in college sports club.

Conclusion: Slightly elevated BMI at young age predicted the incidence of metabolic disorders later in life in Japanese men.

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© 2018 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.

This article is licensed under a Creative Commons [Attribution 4.0 International] license.
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