Poster Sessions - Brain and Nervous System
Voluntary Physical, Not Forced Exercise, Ameliorates Tau Pathology and Cognition in Tauopathy Model Mice
2018 Volume 64 Issue Suppl.1 Pages 74-79
Details
2018 Volume 64 Issue Suppl.1 Pages 74-79
Background: Physical exercise has been considered as an effective non-pharmaceutical measure for the treatment of Alzheimer’s disease (AD). In this report, we described the effect of long-term forced and voluntary exercise on tau protein modification using tauopathy model mice, Tg601.
Methods: 12-month-old non-transgenic and Tg601 mice were subjected to forced and voluntary exercise by means of treadmill (TD) and wheel running (WH), respectively. After 5 months, behavioral analysis was performed by Morris water Maze (MWM) and Y-Maze (YM) test. Tau modification was analyzed by using detergent soluble and insoluble tau fractions from brain homogenate. Neuroinflammation was analyzed by immunohistochemistry (IHC) and the cytokine profile by total cytokine microarray.
Results: The MWM and YM results indicated improvement of cognition only in WH. However, TD-treated mice were unaffected. A marked decrease in sarkosyl insoluble tau, and hyper phosphorylated tau was observed in the WH group. IHC data indicated Iba-1 positive microglia were reduced in WH mice. Cytokine microarray illustrated that IL-1α, IL-1r, IL-9, IL-15r, IFNγ, CRP, ICAM-1, CXCL-12, and TNFα were elevated in TD group, however WH was not altered.
Conclusion: Our findings indicated that voluntary exercise would be beneficial for AD in mice.
