Juntendo Medical Journal
Online ISSN : 2188-2126
Print ISSN : 2187-9737
ISSN-L : 2187-9737
Reviews
Effects of Fasting on Metabolic Hormones and Functions: A Narrative Review
JULIUS FINK MASAMI TANAKASHIGEO HORIE
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JOURNAL OPEN ACCESS

2024 Volume 70 Issue 5 Pages 348-359

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Abstract

The occurrence of the metabolic syndrome and its related diseases such as diabetes are steadily rising in our modern society. Modern food choices and the more sedentary lifestyles largely contribute to this shift in our society’s health. Fasting has been practiced for religious purposes all over the world long time before science showed the benefits of it. The effects of fasting on glucose and fat metabolism are of great interest. Fasting triggers a cascade of changes in the hormonal, microbiome and enzymatic environments, leading to shifted glucose and fat metabolisms. Fasting-induced metabolic function changes are affected by several factors such as sex hormones, lipid-released hormones, growth hormone, insulin, and the gut microbiome, leading to lipolysis and the release of FFA into the bloodstream.

The purpose of this review is to summarize the newest research results on the specific pathways fasting triggers to improve metabolic functions and understand the potential applications of fasting as prevention/treatment of several metabolic conditions.

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© 2024 The Juntendo Medical Society. This is an open access article distributed under the terms of Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original source is properly credited.

This article is licensed under a Creative Commons [Attribution 4.0 International] license.
https://creativecommons.org/licenses/by/4.0/
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