Research on a Minor Organism can also be Benefit the World: The Fascinating Cellular Slime Mold Dictyostelium discoideum

Abstract

　In 1985, when I entered the Graduate School of Science at Kyoto University, I began my research on cellular slime molds, a group of soil microorganisms. The cellular slime mold Dictyostelium discoideum is studied globally as a model organism for cell and developmental biology. I was conducting basic biological research into cell differentiation and migration using D. discoideum, and during this process, our research group made a discovery with potential implications for drug development. Specifically, we found that a chlorinated polyketide named differentiation-inducing factor 1 (DIF-1), derived from D. discoideum, exhibits antitumor activity. Based on this discovery, I began elucidating the mechanism of the antitumor action of DIF-1 and developing anticancer drugs using DIF-1 as a lead compound. During this period, in 1991, I obtained my Ph.D. in research related to D. discoideum cell differentiation, and subsequently served as a Japan Society for the Promotion of Science (JSPS) Special Research Fellow before joining the Institute for Molecular and Cellular Regulation (IMCR) at Gunma University in 1993. I then joined the Graduate School of Health and Sports Sciences at Juntendo University in 2015, where I have been until 2024. Throughout this period, I continued my research on DIF-1 and discovered that DIF-1 and its derivatives possess various biological activities ─ such as anti-diabetic, immunoregulatory, anti-bacterial, and anti-malarial activities ─ that could be applicable in drug development. In this review, I aim to present a segment of both our fundamental and applied research on D. discoideum and DIF-1.