マウス・ラット異種間反復移植血清がマウス胚盤胞の着床におよぼす影響について

抄録

Present experiments were performed to examine the possibility that the limited development of mouse eggs transferred into rat uterus was due to an immunological rejections. Mature virgin female mice of the ICR strain were used as the donor and recipient. Tree kinds of media were used;(1) KRP buffer;(2) 20% rat serum+KRP buffer; and (3) 20% rat serum was after transfer of mouse eggs into rat uterus especially when the transfer was repeated+KRP buffer. Eggs culture and exposure to 3 kinds of media were transfer to the mouse uterus. As summarized in Table 1, exposure of blastocysts to medium (3) caused a significan (P<0.05) inhibition of the implantation rate. It was suggested from the above results that a species-specific antibody appeared after transfer of mouse eggs into rat uterus especially when the transfer was repeated.