抄録
It is reported as a hypothesis that, in the final stage of ovulation, theplasminogen activator acts on the follicular wall to rupture it up and thus toinduce ovulation. The authors applied the excited ovary to tranexamic acid, which is an anti-plasminogen activator, to examine if it would inhibitovulation. Ovaries were obtained from golden hamsters and incubated in vitro. Tranexamic acid was added to the medium at a concentration of 0.196. Inovaries excited at 21:00 and 23:00 of proestrus of the estrus cycle, ovulationrate was 25.096 and 91.696, and the average numburs of ova ovulated were0.25-0.12 and 1.58±0.26, respectively. The number of ova was significantlyfewer than the control.
In this study, it was clear that tranexamic acid inhibited ovulation fromovaries in vitro. The present results indicated that ovulation in culturedovaries was inhibited by blooking plasminogen activator.
