抄録
In order to clarify the relation of carcinogenesis in stomach mucosa to the intestinal metaplasia, the atypism and distribution of intestinal metaplasia and their relationship to the localization of carcinomatous lesion was examined pathologically in all specimens of human stomach with early cancer removed surgically from 51 patients. Based on this study, the qualitative distribution diagram of intestinal metaplasia and cancer was made. The removed stomach was divided in two types, non-metaplastic (41%) and metaplastic (59%), and also subdivided in three types, type M, MC0 and MC. Non-metaplastic type, which intestinal metaplasia apart from cancer was treated as type M. Type MC0 and MC were associated with atypical (At-III) and (At- I and At-II) metaplastic epithelium adjacent to cancer. Intestinal metaplasia ratio calculated from the distribution diagram was increased according to aging. The metaplastic carcinoma adjacent to high degree atypism (type MC0) and low degree atypism (type MC) were associated with tubular adenocarcinoma, 100% and 79%, respectively, in comparison with signet ring cell carcinoma (71%) in non-metaplastic type.
