Abstract
To identify risk factors for developing febrile neutropenia (FN), a retrospective study was conducted at an advanced treatment hospital in Japan. Data from 193 patients with lung, breast, and colorectal cancers undergoing outpatient chemotherapy were analyzed. Patient background information, blood test results, and vital signs were extracted from the electronic health records. Using multivariate logistic regression analysis, factors associated with FN or infection-related fever were determined. The results showed that the therapeutic use of granulocyte-colony stimulating factor (G-CSF) agents, use of antibiotics, and a history of sepsis were significant risk factors for FN. Additionally, body mass index, cancer type, therapeutic use of G-CSF agents and steroids, also contributed to the risk of developing neutropenia. At the beginning of the chemotherapy cycle, our models predicted the onset of infection or neutropenia during the cycle. For the safe continuation of outpatient chemotherapy, the above risk factors should be considered in the treatment plan and management.
