Effects of Mannooligosaccharides from Coffee Mannan on Blood Pressure in Dahl Salt-Sensitive Rats

抄録

Dahl salt-sensitive (Dahl-S) rats, serving as a model of hereditary hypertension, were used to examine the effect of mannooligosaccharides (MOS) on blood pressure. Dahl-S rats were induced to develop hypertension by administering them with a 1.25% salt solution ad libitum. In a 10-wk experimental period, the Dahl-S control and MOS groups developed and maintained significantly higher blood pressure than the Dahl salt-resistant normal control group. The MOS group showed a significantly lower blood pressure than the Dahl-S control group after 5-wk of treatment (p<0.05). In addition, the serum aldosterone level of the MOS group significantly decreased (p<0.05). The findings of this study using a model of hypertensive rats suggest that MOS are able to suppress an elevation in blood pressure.