Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B2C1 Adipocyte Cells

Katsuhiko MINAMINO; Yuri YANAGA; Masaru OHTSURU

doi:10.3177/jnsv.54.250

Regular Paper

Bioactive Substance from Grifola frondosa (Maitake) Mushroom Inhibits CCAAT Enhancer Binding Protein β and δ Expression on C3H10T1/2 B₂C₁ Adipocyte Cells

Katsuhiko MINAMINO, Yuri YANAGA, Masaru OHTSURU

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Keywords: Grifola frondosa (maitake), bioactive compound, adipocyte, CCAAT/enhancer binding protein (C/EBP), mechanism regulation

JOURNAL FREE ACCESS

2008 Volume 54 Issue 3 Pages 250-254

DOI https://doi.org/10.3177/jnsv.54.250

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Abstract

Bioactive compound substances from Grifola frondosa (maitake) inhibited adipocyte differentiation of B₂C₁ preadipocytes. This compound is not related to MAP kinase (ERK1 and ERK2) cascades or β-catenin, which inhibit the expression of Glut4, PPARγ and C/EBPα. The compound reduced the expression time of C/EBPβ and C/EBPδ. These results suggest that the inhibitory action of these bioactive compounds on adipocyte differentiation is exhibited through preadipocytes. They cannot induce the expression of PPARγ or C/EBPα because of the reduced expression time of C/EBPβ and C/EBPδ.

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