Enzymatic Phosphatidylation of Thiamin, Pantothenic Acid, and Their Derivatives

Naomi HIDAKA; Masaaki TAKAMI; Yukio SUZUKI

doi:10.3177/jnsv.54.255

Journal of Nutritional Science and Vitaminology

Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800

Note

Enzymatic Phosphatidylation of Thiamin, Pantothenic Acid, and Their Derivatives

Naomi HIDAKA, Masaaki TAKAMI, Yukio SUZUKI

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Keywords: transphosphatidylation reaction, phospholipase D, phosphatidylthiamin, phosphatidylthiamin disulfides, phosphatidylpantothenic acid

JOURNAL FREE ACCESS

2008 Volume 54 Issue 3 Pages 255-261

DOI https://doi.org/10.3177/jnsv.54.255

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Abstract

Phospholipase D from Streptomyces sp. was found to catalyze the transfer reaction of the dipalmitoylphosphatidyl residue from 1,2-dipalmitoyl-3-sn-phosphatidylcholine to thiamin, pantothenic acid, and their derivatives in a biphasic system. The following phosphatidylated compounds were synthesized: 1,2-dipalmitoyl-3-sn-phosphatidylthiamin, 1,2-dipalmitoyl-3-sn-phosphatidylthiamin propyl disulfide, 1,2-dipalmitoyl-3-sn-phosphatidylthiamin tetrahydrofurfuryl disulfide, 1,2-dipalmitoyl-3-sn-phosphatidylpantothenic acid, and 1,2-dipalmitoyl-3-sn-phosphatidyl-pantothenyl ethyl ether.

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