Journal of Nutritional Science and Vitaminology
Regular Paper
Effect of Vitamin E on Learning and Memory Deficit in Aged Rats
Hirokatsu TAKATSUKei OWADAKouichi ABEMasahiro NAKANOShiro URANO
Author information
JOURNALS FREE ACCESS

Volume 55 (2009) Issue 5 Pages 389-393

Details
Download PDF (588K) Contact us
Abstract

In order to verify whether vitamin E improves the cognitive impairment induced through aging, aged rats fed a vitamin E-supplemented diet had their learning and memory functions assessed in comparison with the aged rats fed a normal diet using a Morris water maze test. Although normal aged rats showed very poor learning ability concerning the place of a platform in the water maze apparatus, the aged rats fed the vitamin E-supplemented diet learned the place with a marked speed in only 5 trials. After old animals showed the maximum learning ability, they were kept in a normal atmosphere for 48 h without a trial followed by an assessment of their memory function using the same apparatus. The vitamin E-supplementation to aged rats resulted in marked retention of their maximum memory function, although normal aged rats showed a significant memory loss of about 60%. Pyrroloquinoline quinone (PQQ), which increases in the production of nerve growth factor, and protects neurons, had a similar effect on cognitive function to that of vitamin E in the aged rats. These results suggest that vitamin E may improve cognitive deficit caused through aging by not only its neuro-protecting effect but an antioxidant efficacy.

Information related to the author
© 2009 by the Center for Academic Publications Japan
Next article

Recently visited articles
feedback
Top