Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
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Consumption of Curcumin Elevates Fecal Immunoglobulin A, an Index of Intestinal Immune Function, in Rats Fed a High-Fat Diet
Yukako OKAZAKIYunkyung HANMai KAYAHARAToshiro WATANABEHirofumi ARISHIGENorihisa KATO
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2010 Volume 56 Issue 1 Pages 68-71

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Abstract

This study was conducted to elucidate the effects of dietary polyphenols on intestinal immunoglobulin A (IgA) response and mucin levels in rats fed a high-fat diet. In experiment 1, rats were fed a high-fat diet with or without several polyphenols including curcumin, rutin, D(+)-catechin, ellagic acid and quercetin at the level of 0.5%. Among the polyphenols examined, consumption of curcumin markedly elevated the level of IgA in feces and colon contents. In experiment 2, rats were fed a high-fat diet or a low-fat diet with or without 0.5% curcumin. Fecal level of IgA was higher in the high-fat diet group than in the low-fat diet group. In the rats fed the high-fat diet, dietary curcumin elevated fecal IgA, but not in those fed the low-fat diet. These results imply a novel effect of curcumin on intestinal IgA in animals fed a high-fat diet.

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© 2010 by the Center for Academic Publications Japan
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