Journal of Nutritional Science and Vitaminology
Online ISSN : 1881-7742
Print ISSN : 0301-4800
ISSN-L : 0301-4800
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The Soy Isoflavone Equol Enhances Antigen-Specific IgE Production in Ovalbumin-Immunized BALB/c Mice
Tohru SAKAISakina FUROKUMariko NAKAMOTOEmi SHUTOToshio HOSAKAYasuhiko NISHIOKASaburo SONE
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Keywords: soy isoflavone, equol, IgE, IL-13
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2010 Volume 56 Issue 1 Pages 72-76

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Abstract

Although an immunomodulatory role of the soy isoflavone genistein has been demonstrated, the effects of other soy isoflavones on induction of antigen (Ag)-specific immune responses are not known. In this study, we therefore investigated the effects of daidzein and equol on ovalbumin (OVA)-specific T cell and B cell responses in BALB/c mice. Mice that had been treated with 20 mg/kg equol showed a significantly higher level of OVA-specific IgE than control mice. Levels of interferon (IFN)-γ and interleukin (IL)-4 production were not different between the control and equol groups. However, IL-13 production level in mice administered 20 mg/kg equol was significantly higher than that in control mice. Strong induction of OVA-specific IgE production by equol was also observed in ovariectomized BALB/c mice, suggesting that the immunomodulatory effect of equol is not affected by endogenous estrogen.

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© 2010 by the Center for Academic Publications Japan
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